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. Author manuscript; available in PMC: 2015 Oct 5.
Published in final edited form as: Cancer Sci. 2015 Mar 3;106(4):421–429. doi: 10.1111/cas.12610

Figure 5. Myc-5 blocks the growth of P493.6 xenografts.

Figure 5

A, Schematic diagram of the xenograft model illustrating timing of tumor implantation and treatment. Eight weeks old SCID mice were subcutaneously injected with P493.6 cells. B, Tumor-growth chart showing the effect of treatment in vivo. Myc-5 (7.5 mg/kg) and doxycycline significantly slowed tumor growth (P<0.001) at termination point in comparison to control group. Representative picture of each group mice (inset). C, FITC-labeled Myc-5 localizes to nucleus of P493.6 xenograft leaving normal tissue unaffected (separated by white line). N: Normal tissue, T: tumor tissue. D, Mean body-weight for each treatment group plotted as function of day after post-injection. E, Comparisons of excised tumor weights for three different treatment groups at the end of study are shown. The data in B, D and E are shown as the mean ± SD. Statistical significance was calculated by Student's t test. ***P < 0.001.