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. Author manuscript; available in PMC: 2015 Oct 5.
Published in final edited form as: Cancer Sci. 2015 Mar 3;106(4):421–429. doi: 10.1111/cas.12610

Figure 6. Histopathology of xenografts in nude mice and illustration of potential mechanism by Myc-5.

Figure 6

A, Tissue sample were analyzed qualitatively for the morphological changes. Magnification of all pictures is ×10 (scale bar 200µm) and ×40 magnification (scale bar 50µm). B–C, Quantitative data of immunohistochemical analysis of BrdU and TUNEL positive staining in each group. The data in B and C are shown as the mean ± SD of three tumor samples from an individual mouse in each group.. Statistical significance was calculated by Student's t test. ***P < 0.001. D, Schematic diagram of the mechanism by which PI polyamide inhibits MYC/MAX interaction to E Box. (I), MYC/MAX dimer binds to E-box and activates MYC target gene expression. (II), Myc-5 occupied the E-box by binding, thereby inhibiting the MYC/MAX interaction to E-box further causing suppression of target gene expression.