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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Cell Mol Gastroenterol Hepatol. 2015 Mar 1;1(2):154–170. doi: 10.1016/j.jcmgh.2015.01.006

Figure 1.

Figure 1

Mechanism of DSS Colitis: DSS Colitis is most essentially a colitis due to loss of epithelial barrier function and entry of luminal organisms or their products into the lamina propria. Such entry results in stimulation of innate and adaptive lymphoid elements and secretion of pro-inflammatory cytokines and chemokines. In addition, it results in the influx of cells with cytotoxic potential such as neutrophils and inflammatory macrophages.