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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Cell Mol Gastroenterol Hepatol. 2015 Mar 1;1(2):154–170. doi: 10.1016/j.jcmgh.2015.01.006

Figure 3.

Figure 3

Mechanism of Cell Transfer Colitis: Cell Transfer Colitis is initiated in lymphopenic (SCID or Rag−/−) mice that are the recipients of naïve CD45RBhi T cells, a cell population that cannot be induced to generate regulatory T cells in a timely fashion to prevent the expansion of effector T cells that mediate inflammation. However, if the naïve T cells are transferred in the company of mature CD45RBlo T cells that already contain regulatory T cells, the latter prevent the development of inflammation. This model thus provides a way of isolating the function of effector cells and regulatory cells.