Table 1.
SZ GWAS genes associated with synapses
| Chr | P-value | Gene | Synaptic function |
|---|---|---|---|
| 4 | 3.441E-08 | CLCN3 | Chloride channel; synaptic plasticity |
| 5 | 1.305E-09 | GRIA1 | AMPARs; synaptic plasticity |
| 7 | 2.358E-14 | ELFN1 | Postsynaptic protein |
| 10 | 5.523E-17 | CALHM1 | Calcium channel; neural excitability |
| INA | Transport to axons and dendrites | ||
| NEURL | Neurogenesis | ||
| 12 | 1.298E-17 | CACNA1C | Calcium channel; neurotransmission |
| 16 | 1.075E-09 | GRIN2A | Mediator of synaptic plasticity |
| 17 | 1.04E-09 | SRR | Activator of NMDARs |
| 22 | 8.076E-12 | CACNA1I | Calcium channel; synaptic plasticity |