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. Author manuscript; available in PMC: 2015 Dec 3.
Published in final edited form as: J Med Chem. 2014 Dec 16;58(2):665–681. doi: 10.1021/jm501165d

Scheme 1a.

Scheme 1a

aReagents and conditions: (a) Br(CH2)4Br, NaHCO3, DMF, microwave irradiation, 165 °C, 12 min, 63% for 6a, 53% for 6b, and 45% for 6c; (b) NaCN, DMSO, 50 °C, 12 h, 71% for 7a, 54% for 7b, and 63% for 7c.