Table 2.

Functional Potencies (EC₅₀) of Selected (−)-Δ⁸-THC Ester Analogues for the rCB1 Cannabinoid Receptor

compd	rCB1 (EC50, nM)a		E(max) (%)d
	3-pointsb	8-pointsc
7a	10–100
2b	<1	0.5 (0.1–1.2)e	92e
8b	1–10
10a	<1	0.9 (0.3–1.5)	89
10b	1–10
7b	1–10
18	1–10
2c	<1	0.4 (0.2–1.2)e	90e
7c	1–10

^aFunctional potencies at rCB1 receptor were determined by measuring the decrease in forskolin-stimulated cAMP levels, as described in Experimental Section.^16,18

^bThree point data were obtained from one experiment (3 points) run in duplicate (less accurate EC₅₀ values).

^cData are average of two independent experiments (8 points) run in triplicate, and 95% confidence intervals for the EC₅₀ values are given in parentheses. EC₅₀ values were calculated using nonlinear regression analysis.

^dForskolin stimulated cAMP levels were normalized to 100% and E_(max) is the maximum inhibition of forskolin stimulated cAMP levels and is presented as the percentage of CP-55,940 response at 500 nM.

^eReported previously.¹⁶