Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Calculated log P and tPSA Values for (−)-Δ8-THC-DMH, 2b, and 10a, and Duration of Their Hypothermic Effects in Rats
| compd | clogPa | tPSAa | duration of hypothermic effects in ratsb |
|---|---|---|---|
| (−)-Δ8-THC-DMH | 9.1 | 29.5 | t > 12 h |
| 2b | 6.6 | 55.8 | t = 6–12 h |
| 10a | 5.0 | 79.5 | t < 6 h |
Calculations were performed using ChemBioDraw Ultra 14.0 software.
Hypothermic effects were determined using equiactive doses of the test compounds.
