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. Author manuscript; available in PMC: 2015 Mar 25.
Published in final edited form as: J Immunol. 2015 Feb 20;194(7):3236–3245. doi: 10.4049/jimmunol.1402764

Figure 4. Both cGAS and Ifi204 are required for the full type I IFN response to F. novicida infection.

Figure 4

mRNA expression levels were measured in uninfected RAW264.7 (WT) cell lines stably expressing Ifi204 (A) or cGAS (C). mRNA expression was normalized to GAPDH and wild-type (WT) RAW264.7 macrophages. Macrophages were infected with wild-type F. novicida at an MOI of 10 for 24 h and type I IFN levels measured (B and D, respectively). *p < 0.05, **p < 0.01, ***p < 0.001. Graphs show the mean ± standard deviation (SD) of triplicate wells and are representative of three independent experiments.