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. Author manuscript; available in PMC: 2016 Apr 5.
Published in final edited form as: J Clin Oncol. 2014 Jan 21;32(6):579–586. doi: 10.1200/JCO.2012.45.2011

Fig 2.

Fig 2

Genetic alterations detectable in circulating cell-free tumor DNA. Tumor cells release small fragments of cell-free DNA into circulation by multiple mechanisms. Cancer-associated genetic alterations such as point mutations, copy number variations, chromosomal rearrangements, and methylation patterns can be detected in circulating cell-free DNA.

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