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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Horm Cancer. 2015 Jan 29;6(0):67–86. doi: 10.1007/s12672-014-0215-9

Fig. 1.

Fig. 1

Effect of AR allele strength on ETV1-induced PIN a C57BL/6 mice carrying a “humanized” AR gene with a short (hAR12Q) or long (hAR48Q) polyglutamine tract were crossed with ETV1-transgenic FVB mice (ETV1Tg) to generate hAR;ETV1Tg mice. Experimental mice were castrated or left intact at 12 weeks, aged to 24 weeks and compared to intact hAR controls. hAR;ETV1Tg mice were then backcrossed to FVB and crossed with Pten+/− mice to generate hAR;ETV1Tg;Pten+/− experimental mice with short (12Q), median (21Q) or long (48Q) Q-tracts. Experimental hAR;ETV1Tg;Pten+/− mice were castrated or left intact at 12 weeks, aged to an average of 43 weeks and compared to hAR;Pten+/− controls. b Representative H&E stained prostates from hAR;ETV1Tg mice. Normal tissue (DLP), hyperplasia (DLP) and mPIN (VP) are shown. Images are 10x with 40x insets. c The proportion of mice with hyperplasia and mPIN in AP, DLP and VP among hAR12Q;ETV1Tg and hAR48Q;ETV1Tg mice. 5-8 lobes per group were analyzed.