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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Horm Cancer. 2015 Jan 29;6(0):67–86. doi: 10.1007/s12672-014-0215-9

Fig. 8.

Fig. 8

ETV1-induced inflammatory expression signature precedes tumorigenesis a Genes that are differentially expressed between hAR;Pten+/− and hAR;ETV1Tg;Pten+/− mice and annotated with inflammation-related GO terms (see Fig. 7A) are shown in the heatmap. Relative expression in prostates of hAR;Pten+/− and hAR;ETV1Tg;Pten+/− mice is shown, as well as expression in the macroscopic prostate tumors. b RWPE-1 cells stably expressing AR and either ETV1 or LACZ were stimulated with 1 nM R1881 or methanol vehicle, and RNA was prepared for qRT-PCR analysis. Expression of the inflammatory genes CXCL16 and NUPR1 were normalized to GAPDH or ACTB, respectively, and plotted relative to RWPE-AR-LACZ cells. Mean and SEM are plotted for biological triplicate samples.