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A,B. Characteristic histological features of PXA. A. Leptomeningeal involvement by pleomorphic, giant and spindle-shaped tumor cells. H&E, 100×. B. Pale and intensively eosinophilic granular bodies with occasional xanthic tumor cells. H&E, 400×. C–E. Histological features of anaplasia. C. Mitotic index ≥ 5/10 HPF, including atypical mitotic figures. H&E. 400×. D. Necrosis and E. endothelial proliferation. H&E, 200×. F. BRAF V600E immunostain: strong labeling of tumor cells. 200×.
