Table 2.
RNA from three separate sets of CGN cultures treated with HK or LK were used for RNA-Seq. List of top 10 (A) up-regulated genes and (B) down-regulated genes after LK treatment. Fold change values, raw p-values and p-values adjusted for multiple testing were calculated using Benjamini-Hochberg test. Genes were considered significantly differentially expressed if they had a false discovery rate of less than 5%.
| A) Up-regulated Genes in LK | B) Down-regulated Genes in LK | ||||
|---|---|---|---|---|---|
| Gene | Fold Change | FDR | Gene | Fold Change | FDR |
| Klrd1 | 82.48 | 1.94E-07 | Npas4 | 50.83 | 5.02E-04 |
| Slcl7a1 | 79.85 | 2.33E-07 | Pthlh | 27.06 | 3.47E-74 |
| Ccin | 74.27 | 3.21E-06 | Txlnb | 19.86 | 3.87E-07 |
| Calhm1 | 71.54 | 1.92E-07 | Bag2 | 15.25 | 1.37E-90 |
| Sohlh1 | 50.58 | 3.44E-04 | Car7 | 14.61 | 7.46E-14 |
| Stra6 | 47.56 | 1.14E-07 | Cacng6 | 13.82 | 7.95E-29 |
| Slcl7a3 | 46.26 | 4.76E-54 | Cytip | 13.25 | 5.32E-29 |
| Dusp9 | 41.64 | 6.65E-08 | Igfbp3 | 13.20 | 7.25E-35 |
| Kcnj15 | 38.81 | 7.71E-04 | Irx3 | 12.43 | 4.21E-16 |
| Gpr113 | 36.52 | 5.43E-38 | RGD1304931 | 11.61 | 1.04E-69 |