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. Author manuscript; available in PMC: 2016 Feb 19.
Published in final edited form as: Chem Biol. 2015 Jan 22;22(2):285–292. doi: 10.1016/j.chembiol.2014.10.023

Table 1.

Comparison of cyclophilin inhibition, HCV NS5A-cyclophilin A complex disruption and genotype 1b replicon inhibition for cyclosporin and sanglifehrin analogues

CypA PPIase
IC50 (nM)		 NS5A-CypA
disruption IC50
(µM)		 HCV Huh5.2 Gt1b
replicon EC50 (nM)		 HCV Gt1b replicon
CC50 (µM)
CsA 9.7 ± 1.30 0.98 ± 0.08 306 ± 141 4.4
Alisporivir 0.8 ± 0.05 0.24 ± 0.02 96 ± 23 11.2
BC544 2.7 ± 0.2 0.36 ± 0.03 125 ± 22 >100
NVP018 0.3 ± 0.03 0.10 ± 0.01 33 ± 10 >100