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. Author manuscript; available in PMC: 2016 Jan 13.
Published in final edited form as: Molecules. 2015 Jan 13;20(1):1192–1209. doi: 10.3390/molecules20011192

Figure 5.

Figure 5

(A) Mg2+ binding rigidifies the TSase-(5F-dUMP)-CH2H4fol complex. Significant (greater than 2σ) differences in 15N-1H order parameters (ΔS2 = S2, Mg2+−S2, EDTA) are shown. (B) The significant changes in panel A are highlighted on a ternary complex structure with a color gradient of white to red representing minimal to maximal changes in S2. Residues with no significant change are colored in and the suggested binding site for Mg2+ is shown in green. Reproduced from ref [83]with permission from the American Chemical Society.