TABLE III.
IL-8 and Neutrophil Correlations with ARI Symptoms
| Symptom score | Pearson correlation coefficient | Regression coefficient | P value |
|---|---|---|---|
| IL-8 | |||
| * WURSS total | 0.068 | 0.0072 | <0.008 |
| * Nasal AUC | 0.057 | 0.0031 | 0.066 |
| Runny nose | 0.13 | 0.18 | <0.00001 |
| Plugged nose | 0.045 | 0.18 | 0.003 |
| Sneezing | −0.024 | −0.13 | <0.0001 |
| Scratchy throat | 0.017 | −0.12 | 0.017 |
| Daily change | 0.058 | −0.18 | <0.002 |
| Neutrophils | |||
| * WURSS total | 0.12 | 0.010 | <0.002 |
| * Nasal AUC | 0.073 | 0.0035 | 0.089 |
| Runny nose | 0.18 | 0.17 | <0.003 |
| Plugged nose | 0.14 | 0.11 | 0.058 |
| Sneezing | −0.0055 | −0.05 | 0.31 |
| Overall illness severity | 0.099 | 0.16 | 0.061 |
| Scratchy throat | −0.033 | −0.13 | 0.034 |
| Think clearly | 0.034 | −0.15 | 0.026 |
| Sleep well | 0.15 | 0.11 | 0.026 |
Notes: Pearson’s correlations are calculated using non-transformed data. Regression coefficients are calculated from the linear model with these variables as covariates, and logarithm of IL-8/Neutrophils as response variable. P-values are based on the Student’s t tests for testing whether specific regression coefficient equals 0.
WURSS = Wisconsin Upper Respiratory Symptom Survey, AUC = area under curve.
*
Regression coefficient from separate linear models with variable as covariate and log (Biomarker) as response variable: log(−Biomarker) ~ Intercept + WURSStotal or log(Biomarker) ~ Intercept + NasaIAUC.