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. Author manuscript; available in PMC: 2009 May 7.
Published in final edited form as: J Neurosci. 2008 Jul 16;28(29):7293–7303. doi: 10.1523/JNEUROSCI.1826-08.2008

Figure 2. PTP inhibition by bpV(phen) treatment rescues dorsal column sensory axons and white matter.

Figure 2

The concentration of bpV(phen), the histological measure, the time following the spinal cord contusion when the treatment was started (start) and the infusion site (site) are indicated below the graph. A) After a 7-day infusion of 30 μM bpV(phen) at the T9 contusion site started immediately after the injury, more sensory axons remained intact than with PBS (0), as measured by the CTB-labeled terminal fiber area in the gracile nucleus. p < the values indicated above the columns. Values are expressed as a percentage of 7 sham operated rats. B) bpV(phen) also protected the dorsal column white matter (WM) at the injury epicenter. A dose response study using 7 day infusions at L/5/6 started immediately after the injury showed that 100 μM bpV(phen) was most effective in protecting gracile nucleus innervation (C, CTB) and T9 dorsal column white matter (D, WM). When started 4 hours after the contusion, 7 day L5/6 bpV(phen) infusions also rescued gracile nucleus innervation (E) and T9 dorsal column white matter (F).