Table 2.

Top overlapping gene ontology pathways.

GO term (biological process)	Old	1mo post-DSB	2mo post-DSB
Up Regulated
T cell activation (GO:0042110)	9.4×10−13	5.2×10−11	2.0×10−3
Immune response (GO:0006955)	2.2×10−18	2.8×10−8	NA
Cell activation (GO:0001775)	5.5×10−18	4.6×10−8	NA
Chemotaxis (GO:0006935)	3.0×10−6	2.8×10−7	1.5×10−3
T cell proliferation (GO:0042098)	2.0×10−6	1.8×10−6	1.3×10−3
Integrin-mediated signaling pathway (GO:0007229)	3.4×10−4	9.0×10−6	2.8×10−3
Lymphocyte proliferation (GO:0046651)	3.0×10−5	2.1×10−5	4.1×10−3
Leukocyte proliferation (GO:0070661)	3.9×10−5	2.4×10−5	4.4×10−3
Mononuclear cell proliferation (GO:0032943)	3.9×10−5	2.4×10−5	4.4×10−3
Cell cycle (GO:0007049)	1.0×10−4	3.2×10−5	2.0×10−2
Cell proliferation (GO:008283)	5.1×10−5	1.5×10−4	1.2×10−2
Regulation of apoptosis (GO:0042981)	2.0×10−3	6.3 ×10−3	NA
Cell adhesion (GO:0007155)	1.8 ×10−5	1.8 ×10−3	NA
Regulation of actin filament polymerization (GO:0030833)	1.5 ×10−2	3.3 ×10−3	NA
Down Regulated
Acute inflammatory response (GO:0002526)	1.2×10−2	1.7×10−5	NA
Steroid metabolic process (GO:0008202)	3.7×10−3	2.2×10−4	NA
Glucose metabolic process (GO:0006006)	1.9×10−2	2.9×10−3	NA
Monosaccharide metabolic process (GO:0005996)	1.6×10−2	3.2×10−3	1.0×10−2
Lipid biosynthetic process (GO:0008610)	1.7×10−6	8.3×10−3	NA

The top 10 upregulated and top 5 downregulated overlapping gene ontology annotations for biological processes for 1 mo post-DSB or 2 mo post-DSB were compared to Old for upregulated and downregulated transcripts. P values were determined using Fisher’s exact test.