Table 2.

Description of employed metrics, where A= algorithm-dependent deformed ROI volume, R= reference anatomic manually segmented ROI volume.

Metric	Symbolic Expression	Description	Full agreement
Volume Overlap	$VO=\frac{|A\cap R|}{\left|R\right|}$	The portion of the reference ROI which is overlapped by the segmentation	1
Dice Similarity Coefficient	$D=\frac{2|A\cap R|}{\left|A\right|+\left|R\right|}$	The portion of overlap between the reference ROI and segmentation relative to the size of the reference ROI plus the size of the segmentation	1
False Negative Dice	$\mathit{FND}=\frac{2|\overline{A}\cap R|}{\left|A\right|+\left|R\right|}$	The volume that the segmentation missed of the reference ROI relative to the size of the reference ROI plus the size of the segmentation	0
False Positive Dice	$\mathit{FPD}=\frac{2|A\cap \overline{R}|}{\left|A\right|+R}$	The volume of the segmentation not found within the reference ROI relative to the size of the reference ROI plus the size of the segmentation	0
95% maximum Hausdorff Distance (HD)	$\begin{array}{l}H(A,R)=max\left(h\left(A,R\right)\right),h\left(R,A\right)∍\\ h(A,R)=\underset{a\in A}{max}\left(d\left(A,R\right)\right)\&d\left(A,R\right)=\underset{g\in G}{min}\Vert a-r\Vert \end{array}$	The maximum distance between a point in the segmentation and that of the reference ROI; for 95% maximum Hasudorrf, ±5%-ile outliers are discarded