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. Author manuscript; available in PMC: 2009 May 8.
Published in final edited form as: J Neurosci. 2008 Jun 25;28(26):6557–6568. doi: 10.1523/JNEUROSCI.0134-08.2008

Figure 6. MEF2CA-ESC-derived neuronal progenitor cells injected into mouse stroke model express neuronal markers and migrate into ischemic areas of the brain.

Figure 6

A, B, Four weeks after transplantation, MEF2CA/EGFP-ESC-derived NPCs (B) but not EGFP (control)-expressing progenitors (A) that were located near the injection site stained for the early neuronal marker TuJ1. Cells were co-labeled with BrdU prior to transplantation for identification purposes; scale bar, 25 µm. C, D, By eight weeks after transplantation, many of the injected MEF2CA/EGFP-ESC-derived NPCs had migrated to an area adjacent to the ischemic zone and expressed the mature neuronal marker NeuN (C); scale bar, 200 µm. Colocalization of EGFP and NeuN can be seen more clearly in the high power inset (D); scale bar, 15 µm.