Table 3.
Tier 1 overall positive outcome rates. Dose groups that achieve the required positive outcome rate to be considered promising as defined by our Tier 1 effectiveness evaluation plan are shaded in yellow.
| Group | Outcome | (Vehicle) 0 mg/kg/day | 10 mg/kg/day | 20 mg/kg/day | 40 mg/kg/day | 60 mg/kg/day |
|---|---|---|---|---|---|---|
| 1-h RNR | Pathology | 4/20 | 0/10 | 1/10 | 2/10 | 0/10 |
| Mitochondria | 10/20 | 6/10 | 4/10 | 5/10 | 4/10 | |
| Total positive outcome rate | 14/40 (35%) | 6/20 (30%) | 5/20 (25%) | 7/20 (35%) | 4/20 (20%) | |
| 6-h RNR | Pathology | 2/10 | 2/10 | 4/10 | 1/10 | 3/10 |
| Mitochondria | 5/10 | 7/10 | 6/10 | 5/10 | 6/10 | |
| Total positive outcome rate | 7/20 (35%) | 9/20 (45%) | 10/20 (50%) | 6/20 (30%) | 9/20 (45%) | |
| 1-h CCI | Pathology | 4/20 | 1/10 | 4/10 | 2/10 | 6/10 |
| Mitochondria | 9/20 | 6/10 | 4/10 | 6/10 | 5/10 | |
| Total positive outcome rate | 13/40 (33%) | 7/20 (35%) | 8/20 (40%) | 8/20 (40%) | 11/20 (55%) | |
| 6-h CCI | Pathology | 2/10 | 4/10 | 5/10 | 3/10 | 4/10 |
| Mitochondria | 5/10 | 7/10 | 4/10 | 3/10 | 5/10 | |
| Total positive outcome rate | 6/20 (30%) | 11/20 (55%) | 9/20 (45%) | 6/20 (30%) | 9/20 (45%) |
Abbreviations: RNR = rapid nonimpact rotation; CCI = controlled cortical impact.