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. Author manuscript; available in PMC: 2008 Sep 23.
Published in final edited form as: Cell Mol Life Sci. 2008 Aug;65(15):2407–2418. doi: 10.1007/s00018-008-8195-y

Figure 1.

Figure 1

Dual effects of salicylate on distortion product otoacoustic emission (DPOAE) in measurement in vivo. (A) Acute inhibition of salicylate on DPOAE. The distortion product of 2f1 − f2 was measured at f0 = 3 kHz, f1/f2 = 1.2, L1/L2 = 55/50 dB SPL. A vertical arrow indicates a salicylate injection. Salicylate reversibly inhibited acoustic emissions. The DPOAE recovered after 8 h. Inset: The spectrum of recorded acoustic response to two-tone stimuli. The noise floor level was less than −15 dB SPL. (B) Increase in acoustic emission in long-term administration of salicylate. Asterisks indicate p < 0.01 (ANOVA).