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. Author manuscript; available in PMC: 2008 Sep 23.
Published in final edited form as: Cell Mol Life Sci. 2008 Aug;65(15):2407–2418. doi: 10.1007/s00018-008-8195-y

Figure 6.

Figure 6

The effect of salicylate on OHC distortion product generation. (A) Spectrum and distortion products generated by OHC to two-sinusoidal stimulation in patch-clamp recording. The response was recorded at f1 = 976.56 Hz, f2 = 1171.87 Hz, and Vp-p = 25 mV. (B) Long-term administration of salicylate increases OHC distortion products. The distortion products were recorded from OHCs dissociated from animals (n=8) with injection of salicylate for 2 weeks and normalized to recording from the OHCs dissociated from normal animals. (C, D) Acutely inhibitory effect of salicylate on OHC generating distortion products. The distortion products in (C) were normalized to the pre-perfusion values. (D) The cubic distortion product of 2f1 − f2 recorded at pre-perfusion, perfusion of 10 mM salicylate for 2 min, and washout at 3 min and 5 min during patch-clamp recording. The response was quickly recovered after washout of salicylate.