Table 1.

Summary of Mediators of Episome Stability and Previously Identified Roles in HPV Biology.

Gene	Effect on HPV Episomes [6]; Function	Other Known HPV Roles
MGMT	Repressor of AVPs; Base excision repair methyltransferase	Proteolytic Target of E6 [139] Promoter methylated in cervical cancer [140]
TP73	Repressor of AVPs; Tumor suppressor; Transcription Factor (P53 family)	Promoter methylated in cervical cancer [140]; linked to cervical carcinogenesis [141]
MLH3	Repressor of AVPs; knockdown decreases normal HPV episome levels; mutL homolog	Associated with risk of HPV infection and cervical carcinogenesis [142]
TYMS	Repressor of AVPs; Thymidylate synthetase	Associated with infection by high-risk HPV [143]
FANI	Repressor of AVPs; FANCD2-associated nuclease; Fanconi anemia pathway	Fanconi anemia pathways implicated in HPV infection [116,144]
FANCC	Knockdown decreases normal episome levels; Fanconi anemia pathway	Fanconi anemia pathways implicated in HPV infection [116,144]
FANCF	Knockdown increases normal episome levels; Fanconi anemia pathway	Fanconi anemia pathways implicated in HPV infection [116,144]
MTOR	Knockdown decreases normal episome levels; kinase, central regulator	MTOR activated by HPV E6 [145]; implicated in HPV infection/entry [146]