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. Author manuscript; available in PMC: 2008 Dec 19.
Published in final edited form as: J Neurosci. 2008 Jun 18;28(25):6516–6525. doi: 10.1523/JNEUROSCI.0390-08.2008

Figure 7.

Figure 7

The κ-OR agonist, U50488, attenuates LC activation by hypotensive stress. (A) Representative traces showing LC spontaneous discharge rates during sodium nitroprusside infusion (bar) in rats pretreated with ACSF or U50488 (100 ng). The abscissa indicates the time in seconds. The ordinate indicates discharge rate (Hz). (B) Mean time course of LC spontaneous discharge rates during sodium nitroprusside administration in rats pretreated with ACSF (open circles; n=8) or U50488 (closed circles; n=9). The abscissa indicates time in minutes, while the ordinate indicates percent increase in LC discharge. A one way repeated measures ANOVA revealed a significant effect of sodium nitroprusside administration (F(3,27)=9.738; p<0.0005); whereas there was no significant effect after U50488 pretreatment (F(3,35)=1.544; p>0.05). A two way repeated measures ANOVA revealed a main effect of pretreatment (F(1,42)=5.87; p=0.03). *p<0.05; statistically significant from ACSF; Fisher’s PLSD post hoc analysis).