Table 1.
Basic Measurements for the 22 C57Bl/6 Pkd1RC/RC Mice, by Age and Sex.a
| Measurement | 9F | 9M | 12F | 12M | 15F | 15M |
|---|---|---|---|---|---|---|
| Body Weight (g) | 23.8±0.4 | 25.8±1.8 | 24.1±1.5 | 29.5±2.0 | 23.9±1.5 | 28.5±2.0 |
| Kidney Weight (g) | 0.9±0.2 | 0.6±0.1 | 1.0±0.2 | 0.7±0.1 | 1.0±0.3 | 0.7±0.1 |
| KW/BW (%) | 3.8±0.7 | 2.2±0.2 | 4.0±0.9 | 2.2±0.2 | 4.3±1.0 | 2.5±0.3 |
| BUN | 45±19 | 18±3 | 74±36 | 21±4 | 93±28 | 28±3 |
| H&E Cystic Index (%) | 22±5 | 8±3 | 42±12 | 11±5 | 42±11 | 16±9 |
| PSR Fibrotic Index (%) | 17±6 | 2±1 | 16±7 | 5±1 | 16±6 | 6±8 |
| TRI Fibrotic Index (%) | 18±6 | 2±1 | 14±5 | 8±3 | 18±4 | 9±10 |
a
Data is presented as mean±standard deviation. Cystic index was measured in H&E stained histological sections, and fibrotic index was measured by both Picro-Sirius Red and Masson’s trichrome stained histological sections.
Abbreviations: BUN, Blood Urea Nitrogen test; H&E, Hematoxylin and Eosin histological staining; PSR, Picro-Sirius Red histological staining; TRI, Masson’s trichrome histological staining