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. Author manuscript; available in PMC: 2015 Apr 9.
Published in final edited form as: Exp Biol Med (Maywood). 2015 Jan;240(1):3–7. doi: 10.1177/1535370214564534

Figure 1.

Figure 1

The new cover for Experimental Biology and Medicine (EBM) that shows the hermeneutic circle of biology on the right (front cover) and the topical areas of EBM on the left (back cover). The circle begins with the animal or organism at the top and progresses counterclockwise through organs, cells, metabolic and signaling networks, biomolecules, and finally the genome at the bottom, thereby representing the reductionist limit of biology. Continuing up the right side through the synthesis of molecules, instrumented and controlled cells, engineered tissues, and engineered organs (including organs for regenerative medicine and organ-on-chip microphysiological systems), the circle closes with a representation of the human that integrates these syntheses. It may be necessary to traverse the circle multiple times, and also to employ corresponding circles for the classic biological model organisms that range from bacteria and yeast to zebrafish.