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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Alzheimers Dement (Amst). 2015 Mar 1;1(1):14–23. doi: 10.1016/j.dadm.2014.11.013

Figure 1. Atlas-Based Segmentation ma-FSLDDMM with Selection, Illustrated for a Single Subject.

Figure 1

A, 38 individual sa-FSLDDMM hippocampal segmentations and a voxel-wise average were first generated for the subject. B, surfaces with corresponding vertices were created for each of the 38 segmentations and the average, using a previously developed template surface injection procedure.[35, 36] C, sum-of-squared errors between the average surface and each sa-FSLDDMM surface were calculated. D, Across all subjects, 14 sa-FSLDDMM maps consistently showed substantially larger error than others and were subsequently removed from further analysis. E, new average segmentation.

Abbreviations: ma, multi-atlas; sa, single-atlas; FSLDDMM, FreeSurfer-initiated Large-Deformation Diffeomorphic Metric Mapping