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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Mol Oncol. 2015 Apr 2;9(7):1371–1383. doi: 10.1016/j.molonc.2015.03.008

Figure 8. Effect of tocilizumab on erlotinib resistance in vivo.

Figure 8

Erlotinib-resistant SQ20B tumor bearing mice (n = 10 per treatment group) were treated as described in the methods section. Tumor volumes were plotted against treatment day. IgG: immunoglobulin G (A), TOC: tocilizumab (B), ERL: erlotinib (C), TOC/ERL: tocilizumab in combination with erlotinib (D). Solid lines and dashed lines represent male (n=5) and female (n=5) mice respectively. Bar graph shows average tumor volumes for each treatment group at treatment day 15 (E). Error bars represent ± standard error of the mean (SEM). *p<0.05. (F) Kaplan-Meier plot of survival data.