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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Cell Mol Life Sci. 2015 Apr 3;72(14):2657–2663. doi: 10.1007/s00018-015-1895-1

Fig. 1.

Fig. 1

Two models for timing and location of progenitor commitment to the thymic B cell lineage. This figure shows two possible pathways for how cells might undergo B lineage restriction within the thymus. 1) Circulating progenitors (such as the CLP-2 and CTP described in the text) enter the thymus already partially restricted to the T or B cell lineage, and 2) Lineage decision occurs intrathymically from multipotent progenitors.