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. Author manuscript; available in PMC: 2015 Apr 15.
Published in final edited form as: Bioscience. 2014 Dec 1;64(12):1092–1102. doi: 10.1093/biosci/biu181

Figure 8.

Figure 8

The principal mechanism for transduction of odorous stimuli in vertebrate olfactory cilia. The parallel horizontal lines represent the inner and outer faces of the ciliary membrane of one cilium on an olfactory sensory neuron. R, odorant-receptor protein; G, Golf, a G-protein; AC, type III adenylyl cyclase; ATP, adenosine 5′-triphosphate; cAMP, cyclic AMP (adenosine 3′:5′-cyclic monophosphate); Na+, sodium ions; Ca2+, calcium ions; shaded rectangles, a cation-conducting channel activated by cAMP; shaded ellipses, a Ca2+-gated channel that conducts chloride ions; Cl−, chloride ions. Modified from Kleene SJ (2002) “The calcium-activated chloride conductance in olfactory receptor neurons.” Current Topics in Membranes 53: 119–134, copyright 2002, with permission from Elsevier.