Skip to main content
. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Clin Transl Sci. 2015 May 11;8(6):848–856. doi: 10.1111/cts.12282

Figure 2. Nociceptive Signaling in the Amygdala.

Figure 2

Dopamine acts within the amygdala. Via K+ channels and D2-like receptors, dopamine leads to decreased glutamate secretion. Glutamate activates group 1 metabotropic glutamate receptors, leading to the activation of G-proteins, phospholipase C, cleaving of PIP2 into DAG and IP3, and the opening of intracellular calcium channels. Once open, calcium channels release calcium into amygdala cells, leading to a variety of excitatory effects that cause increased nociception.