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. Author manuscript; available in PMC: 2018 May 4.
Published in final edited form as: J Neurosci. 2010 Aug 11;30(32):10667–10682. doi: 10.1523/JNEUROSCI.1387-10.2010

Figure 11.

Figure 11

GABAA receptor blockers enhance optical signals in SC. A, Control trace from a single photodiode within the SGS following SGS stimulation (N = 1). Inset, Time course of drug application for the two components, the initial-spike and the after-depolarization. The gray bar indicates the time of addition of 50 μm GABAA receptor blocker (SR-95531). The white bar indicates the time of addition of 50 μm GABAA receptor blocker plus 50 μm APV. B, Optical signal as in A after addition of GABAA receptor blocker (SR-95531) (N = 1). C, Optical signal as in A after addition of GABAA receptor blocker plus APV (N = 1). The arrow indicates the time of stimulation. Di, Percentage change of the initial-spike component (0–10 ms) from control following bath application of GABAA receptor blocker (bicuculline or SR-95531, N = 7). Shades of gray indicate stimulation (Stim) site and recording layer. Vertical lines through the bars indicate SE. *p < 0.05. Dii, Percentage change of the after-depolarization component (20–160 ms) from control following bath application of GABAA receptor blocker (N = 7). E, Same as in D, after addition of GABAA receptor blocker and APV (SGS stimulation only).