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. Author manuscript; available in PMC: 2016 Jun 24.
Published in final edited form as: Stem Cells. 2015 Jun 4;33(7):2306–2319. doi: 10.1002/stem.2042

Figure 1. NSPCs in adult mouse subventricular zone express enzymes required for fatty acid oxidation.

Figure 1

Cells expressing Medium Chain Acyl CoA Dehydrogenase (MCAD, A–E) and TriFunctional Protein (TFP, F–J) are observed in the subventricular zone (A, F) and hippocampal dentate gyrus (B, G). A majority of cells expressing these enzymes in SVZ are observed to be co-labelled with SOX2, while none of the cells expressing fatty acid oxidation enzymes in dentate gyrus are labelled with SOX2 (C, H). Higher-magnification images of MCAD+ cells (D–E) and TFP+ cells (I–J) in SVZ (D, I) and DG (E, J) are shown. In SVZ, fewer than 5% of MCAD+ cells co-label with KI67 and fewer than 5% of KI67+ cells co-label with MCAD. Most MCAD+ cells (in red) do not co-label with GFAP+ astrocytes (K–O), S100B+ ependymal cells (P–T), or DCX+ neuroblasts (U–Y). All tissues were stained with the pan-nuclear marker Hoechst (in blue) to demonstrate total cell number. Scale bars represent 20 µm.