Cortical bone phenotype histomorphometric analysis of 6 week-old WT and CD166−/− mid-shaft femurs. Dual fluorochrome labeling of (A) WT and (B) CD166−/− femurs, original magnification, 10X (inset 20X). (C) T.Ar., (D) Ct.Ar, (E) Periosteal BFR/BS, and (F) Endosteal BFR/BS. n=6–8 mice/group. Results are presented as the mean ± SE. *Indicates significant interaction between genotype and sex, with post-hoc analyses indicating sex-specific genotype differences (p<0.05). #Indicates significant main effect for genotype, with no significant interaction found between genotype and sex (p<0.05).