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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Toxicol Rep. 2015;2:702–715. doi: 10.1016/j.toxrep.2015.03.015

Figure 2.

Figure 2

Toxicity of zinc oxide nanoparticles (ZnO NP) compared to ZnO Bulk and Zn Ion Equivalent controls with 0.5% DMSO vehicle in five-day embryonic zebrafish bioassay under two medium conditions (water and embryo medium). The Zn Ion Equivalent represents the approximate amount of dissolved zinc present in ZnO NP samples as determined by inductively coupled plasma optical emission spectrometry. Total affected represents the combined percent of zebrafish with mortality or any morphological malformation(s) at 120 hours post fertilization. For the ZnO NP prepared in water and embryo medium, the error bars represent the range in mean percent response (3 experiments and 2 experiments respectively, n=32 per experiment per concentration). For the other exposures, the data represents the percent response of 1 experiment, n = 32 per concentration. For ZnO NP (*) and Zn Ion Equivalent (#) data, symbol indicates concentrations where percent prevalence is significantly above background (p<0.05 Fisher’s Exact Test) for all experiments studied.