. Author manuscript; available in PMC: 2015 Jun 16.

Published in final edited form as: Exp Biol Med (Maywood). 2014 Sep 21;240(2):145–155. doi: 10.1177/1535370214549531

Table 1.

NMDA receptor and dopamine-related gene expression changes resulting from repeated ketamine and chronic ketamine

Gene	Model	Repeated	Chronic	References
grin1	PND7 Rat-ketamine	+	nd	^42–44
grin2a	PND7 rat-ketamine	+	nd	⁴²
grin2b	PND 7 rat-ketamine	−	nd	⁴²
grin2c	PND7 rat-ketamine	+	nd	⁴²
TH	Adult mice-Ketamine	nd	+	¹⁸
DRD1	Adult mice-ketamine	nd	+	¹⁸
DRD2	Adult mice-ketamine	nd	+	¹⁸
DAT	Adult mice-ketamine	nd	+	¹⁸

+: increased specific gene mRNA level; –: decreased specific gene mRNA level; nd: not determined; PND7: seven-day-old Sprague Dawley rat; Grin 1: glutamate receptor, ionotropic, NMDA1; Grin2a: glutamate receptor, ionotropic, NMDA2a; Grin2b: glutamate receptor, ionotropic, NMDA2b; Grin2c: glutamate receptor, ionotropic, NMDA2c; TH: TH tyrosine hydroxylase; DRD1: dopamine receptor 1; DRD2: dopamine receptor 2; DAT: dopamine transporter.