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. Author manuscript; available in PMC: 2015 May 19.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Mar 28;19(10):2722–2727. doi: 10.1016/j.bmcl.2009.03.118

Scheme 4.

Scheme 4

Reagents and conditions: (a) LiOH, THF/H2O, 92%; (b) HN(OCH3)CH3, EDC·HCl, HOBt, DMF, rt, 12 h, 90%; (c) thiazole, n-BuLi, −78 °C, 2.5 h, 70%; (d) TFA/H2O, 4 h, >99%; (e) Cbz-Val-Leu-OH, EDC·HCl, HOBt, DMF, rt, 12 h followed by HPLC purification.