Skip to main content
. Author manuscript; available in PMC: 2015 May 19.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Mar 28;19(10):2722–2727. doi: 10.1016/j.bmcl.2009.03.118

Table 1.

Structure and activity of the synthesized CF3-inhibitors

Entry Compound Structurea Kib (µM)
1 1a graphic file with name nihms690708t1.jpg 116 ± 14
2 1b graphic file with name nihms690708t2.jpg 135 ± 32
3 8a graphic file with name nihms690708t3.jpg 363 ± 128
4 8b graphic file with name nihms690708t4.jpg 21.0 ± 4.3
5 8c graphic file with name nihms690708t5.jpg 34.1 ± 4.1
6 8d graphic file with name nihms690708t6.jpg 297 ± 49
7 8e graphic file with name nihms690708t7.jpg 584 ± 167
a

Cbz, benzyloxycarbonyl.

b

Ki, inhibition constant against SARS-CoV 3CLpro.