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. Author manuscript; available in PMC: 2015 May 19.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Mar 28;19(10):2722–2727. doi: 10.1016/j.bmcl.2009.03.118

Table 2.

Structure and activity of the synthesized thiazolyl and benzothiazolyl inhibitors

Entry Compound Structurea Kib (µM)
1 8b graphic file with name nihms690708t8.jpg 21.0 ± 4.3
2 14a graphic file with name nihms690708t9.jpg 478 ± 193
3 14b graphic file with name nihms690708t10.jpg 112 ± 34
4 21 graphic file with name nihms690708t11.jpg 2.20 ± 0.8
5 26 graphic file with name nihms690708t12.jpg 45.2 ± 7.8
6 14c graphic file with name nihms690708t13.jpg 462 ± 145
7 14d graphic file with name nihms690708t14.jpg 614 ± 139
8 14e graphic file with name nihms690708t15.jpg 49.3 ± 10
9 14f graphic file with name nihms690708t16.jpg 159 ± 25
a

Cbz, benzyloxycarbonyl.

b

Ki, inhibition constant against SARS-CoV 3CLpro.