Table 2.
Most significantly associated SNPs.
| SNP | Minor Allele |
MAF | OR | 95% CI | p-value | |
|---|---|---|---|---|---|---|
| Discovery1 | ||||||
| rs7661530 | T | 0.33 | 1.27 | (1.17–1.39) | 6.1 ×10−8 | |
| rs6838116 | A | 0.33 | 1.28 | (1.17–1.40) | 3.1 ×10−8 | |
| rs7675300 | A | 0.31 | 1.27 | (1.16–1.39) | 1.1 ×10−7 | |
| rs16870989 | A | 0.31 | 1.27 | (1.16–1.39) | 1.1 ×10−7 | |
| rs145489027 | A | 0.30 | 1.30 | (1.19–1.42) | 1.0 ×10−8 | |
| rs1495509 | C | 0.31 | 1.27 | (1.17–1.39) | 7.8 ×10−8 | |
| Replication | ||||||
| eMERGE2 | ||||||
| rs7661530 | T | 0.35 | 1.24 | (0.96–1.59) | 0.09 | |
| rs7675300 | A | 0.33 | 1.32 | (1.01–1.70) | 0.04 | |
| rs16870989 | A | 0.33 | 1.28 | (0.98–1.65) | 0.06 | |
| rs145489027 | A | 0.32 | 1.28 | (0.98–1.68) | 0.07 | |
| rs1495509 | C | 0.33 | 1.28 | (0.98–1.65) | 0.06 | |
| GoDARTS3 | ||||||
| rs7661530 | T | 0.37 | 1.05 | (0.89–1.23) | 0.84 | |
| rs6838116 | A | 0.37 | 1.08 | (0.95–1.20) | 0.57 | |
| rs16870989 | A | 0.34 | 1.15 | (1.01–1.30) | 0.03 | |
| rs145489027 | A | 0.33 | 1.12 | (0.99–1.27) | 0.08 | |
| rs1495509 | C | 0.34 | 1.15 | (1.01–1.30) | 0.03 | |
| Meta-analysis | ||||||
| rs7661530 | T | -- | 1.22 | (1.13 – 1.31) | 9.6×10−8 | |
| rs68381164 | A | -- | 1.17 | (1.10 – 1.24) | 4.2×10−7 | |
| rs76753004 | A | -- | 1.27 | (1.17 – 1.39) | 1.4 ×10−8 | |
| rs16870989 | A | -- | 1.23 | (1.15 – 1.32) | 4.9 ×10−9 | |
| rs145489027 | A | -- | 1.24 | (1.16 – 1.33) | 2 ×10−9 | |
| rs1495509 | C | -- | 1.23 | (1.15 – 1.32) | 1.9 ×10−9 | |
1
From a multivariable logistic regression assuming an additive genetic model and adjusted for 10 PCs, birth year and sex.
2
From a multivariable logistic regression (157 cases and 769 controls) assuming an additive genetic model and adjusted for 3 PCs, birth year, sex.
3
From a meta-analysis (710 cases and 3,599 controls), adjusted for age and sex. The p-value for the Q-score p-value was >0.05 for each SNP.
4
Based on only 2 data sets.