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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Papillomavirus Res. 2015 Dec 1;1:12–21. doi: 10.1016/j.pvr.2015.05.001

Fig. 2. Poly-ICR induces HPV16-exposed LC to upregulate CCR7 and migrate to CCL21 in vitro.

Fig. 2

LC were exposed to HPV16 prior to s-Poly-I:C (Poly-ICR) treatment as described. (A) CCR7 expression was analyzed by flow cytometry. Data represent mean fold increase in CCR7 expression (± SEM) relative to untreated LC based on MFI (N=10 individual donors). (B) In vitro migration assay. LC were analyzed for migration through a transwell insert to CCL21 or medium alone. Shown is the mean number of LC migrating to CCL21 (black bars) compared to spontaneous migration (± SEM) relative to untreated LC (N=6 individual donors). **p<0.01 compared to untreated LC and LC exposed to HPV16 (one-way ANOVA, Tukey's post-test).