Skip to main content
. Author manuscript; available in PMC: 2016 Sep 20.
Published in final edited form as: Genes Chromosomes Cancer. 2015 Aug 14;54(11):702–715. doi: 10.1002/gcc.22281
Score (dbtype) Categorical Prediction
SIFT (sift) D: Deleterious (sift<=0.05); T: tolerated (sift>0.05)
PolyPhen 2 HDIV (pp2_hdiv) D: Probably damaging (>=0.957), P:possibly damaging (0.453<=pp2_hdiv<=0.956); B:benign (pp2_hdiv<=0.452)
PolyPhen 2 HVar (pp2_hvar) D: Probably damaging (>=0.909), P:possibly damaging (0.447<=pp2_hdiv<=0.909); B:benign (pp2_hdiv<=0.446)
LRT (lrt) D: Deleterious; N: Neutral; U: Unknown
MutationTaster (mt) A” (“disease-causing-automatic”); “D” (“disease-causing”); “N” (“polymorphism”); “P” (“polymorphism-automatic”)
MutationAssessor (ma) H: high; M: medium; L: low; N: neutral. H/M means functional and L/N means non-functional
FATHMM (fathmm) D: Deleterious; T: Tolerated
MetaSVM (metasvm) D: Deleterious; T: Tolerated
MetaLR (metalr) D: Deleterious; T: Tolerated
CADD Combined Annotation Dependent Depletion