Table 2.
Adjusted Geometric Means of Sex Hormone Levels by Timing of Bilateral Oophorectomy
| Hormone | Natural Menopause | Any Oophorectomy | P2 | Premenopausal Oophorectomy | Postmenopausal Oophorectomy | P3 | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | Mean (95%CI)1 | n | Mean (95%CI) | n | Mean (95%CI) | n | Mean (95%CI) | |||
| Estradiol (pg/ml) | 1388 | 5.4 (5.3, 5.6) | 225 | 5.3 (4.9, 5.7) | 0.52 | 199 | 5.3 (4.9, 5.8) | 26 | 5.3 (4.4, 6.5) | 0.81 |
| Estrone (pg/ml) | 1332 | 24.2 (23.5, 24.8) | 211 | 23.8 (22.2, 25.8) | 0.79 | 187 | 23.6 (21.8, 25.6) | 24 | 25.2 (21.0, 30.3) | 0.78 |
| Estrone Sulfate (pg/ml) | 1066 | 222.4 (213.1, 231.9) | 160 | 240.6 (213.9, 270.7) | 0.23 | 142 | 244.5 (215.2, 277.7) | 18 | 219.7 (162.6, 296.8) | 0.40 |
| Testosterone (ng/dL) | 1494 | 20.8 (20.2, 21.3) | 225 | 15.5 (14.4, 16.7) | <0.0001 | 199 | 15.4 (14.2, 16.7) | 26 | 15.6 (13.2, 18.9) | <0.00014 |
| DHEAS (μg/dL) | 1090 | (57.0, 62.9) | 163 | 60.0 (51.6, 68.3) | 0.95 | 146 | 60.1 (51.9, 69.5) | 17 | 56.5 (39.1, 81.7) | 0.93 |
| Prolactin (ng/mL) | 1150 | 9.2 (8.9, 9.4) | 176 | 9.1 (8.4, 9.8) | 0.88 | 155 | 9.1 (8.4, 10.0) | 21 | 8.8 (7.2, 10.8) | 0.93 |
| SHBG (nmol/L) | 1460 | 58.1 (56.7, 59.5) | 237 | 53.8 (50.4, 57.5) | 0.04 | 208 | 52.2 (48.6, 56.2) | 29 | 62.0 (53.0, 72.4) | 0.025 |
Adjusted for age at blood draw, fasting status, date of blood draw, time of blood draw, age at first birth/parity, BMI at blood draw, alcohol consumption, family history of breast cancer, personal history of benign breast disease, past HT use, and age at menopause.
P – value based on a t-test from a fixed effects model.
P – value based on global F-test from a fixed effects model.
Oophorectomy defined as both ovaries removed with or without a hysterectomy (1 woman had a premenopausal bilateral oophorectomy without a hysterectomy and 4 women who had a postmenopausal bilateral oophorectomy without a hysterectomy).
P-value for pairwise comparisons: premenopause oophorectomy vs. natural menopause p<0.0001; postmenopause oophorectomy vs. natural menopause p=0.003; premenopause oophorectomy vs. postmenopause oophorectomy p=0.80
P-value for pairwise comparisons: premenopause oophorectomy vs. natural menopause p=0.008; postmenopause oophorectomy vs. natural menopause p=0.42; premenopause oophorectomy vs. postmenopause oophorectomy p=0.05