Table 3.

Adjusted Geometric Means of Sex Hormone Levels by Timing of Simple Hysterectomy

	Natural Menopause		Any Hysterectomy			Premenopausal Hysterectomy		Postmenopausal Hysterectomy
Hormone	n	Mean (95%CI)1	n	Mean (95%CI)	P2	n	Mean (95%CI)	n	Mean (95%CI)	P3
Estradiol (pg/ml)	1388	5.5 (5.3, 5.6)	242	5.8 (5.4, 6.2)	0.14	205	5.7 (5.3, 6.2)	37	5.8 (5.0, 6.9))	0.35
Estrone (pg/ml)	1332	24.2 (23.5, 24.9)	229	24.9 (23.4, 26.6)	0.38	194	24.6 (22.9, 26.4)	35	26.4 (22.8, 30.6)	0.49
Estrone Sulfate (pg/ml)	1066	223.9 (214.9, 233.4)	177	216.6 (195.9, 239.5)	0.55	149	209.0 (187.2, 233.3)	28	257.5 (204.3, 324.5)	0.23
Testosterone (ng/dL)	1494	20.7 (20.2, 21.3)	256	19.1 (17.9, 20.4)	0.03	219	18.9 (17.6, 20.2)	37	20.1 (17.3, 23.4)	0.054
DHEAS (μg/dL)	1090	59.6 (56.8, 62.5)	191	51.1 (45.6, 57.3)	0.02	163	48.2 (42.6, 54.5)	28	69.5 (52.3, 92.5)	0.0045
Prolactin (ng/mL)	1150	9.1 (8.9, 9.4)	181	9.6 (8.9, 10.3)	0.23	155	9.6 (8.9, 10.4)	36	9.3 (7.7, 11.1)	0.45
SHBG (nmol/L)	1460	58.1 (56.7, 59.5)	249	55.4 (52.3, 58.7)	0.15	213	55.5 (52.1, 59.2)	26	54.8 (47.9, 62.7)	0.34

Adjusted for age at blood draw, fasting status, date of blood draw, time of blood draw, age at first birth/parity, BMI at blood draw, alcohol consumption, family history of breast cancer, personal history of benign breast disease, past HT use, and age at menopause

²P – value based on a t-test from a fixed effects model.

³P – value based on a global F-test from a fixed effects model.

Simple hysterectomy defined as uterus removed and both ovaries intact.

⁴P-value for pairwise comparisons: premenopausal hysterectomy vs. natural menopause p=0.01; postmenopausal hysterectomy vs. natural menopause p=0.70; premenopausal hysterectomy vs. postmenopausal hysterectomy p=0.44

⁵P-value for pairwise comparisons: premenopausal hysterectomy vs. natural menopause p=0.002; postmenopausal hysterectomy vs. natural menopause p=0.29; premenopausal hysterectomy vs. postmenopausal hysterectomy p=0.02