Table 2.

Transduction ability.

	Receptor	BW	Mutation	Ref.
G protein binding pocket	V2R	3.50	R→H	73
	MC4R	3.53	T→I	48
	LHCGR	6.34	A→V	167
	FSHR	6.36	R→C	188
	LHCGR	7.55	I→K	25,74,189
Central cluster	MC4R	2.50	D→N	190
	V2R	2.50	D→N	191–193
	MC4R	3.40	I→T	194
	LHCGR	3.43	L→R	64
	MC4R	6.43	V→I	172,184,195
	LHCGR	6.45	C→R	14
	TSHR	7.45	N→S	196
	V2R	7.50	P→S	75
Cluster helices I and II	V2R	1.39	L→F	197
	LHCGR	1.41	L→P	198
	MC4R	1.43	G→D	153
	MC4R	1.43	G→V	153
	FSHR	2.61	A→T	199
	MC4R	2.62	I→S	184
Outliners	MC4R	4.51	A→T	49,195
	LHCGR	6.59	A→P	76