Table 3.

Ligand binding affinity.

GOF: Decreased KD				LOF: Increased KD
Receptor	Mutation	BW	Ref.	Receptor	Mutation	BW	Ref.
LHCGR	M→T	2.43	19,60,155,156	MC4R	E→K	1.49	153
TSHR	M→V	2.53	19,200	MC4R	N→S	1.50	25,49,173,184,201
TSHR	S→R	3.36	19,160,196	MC4R	N→D	2.57	25,49,173,195
TSHR	V→A	3.40	19,160,202,203	MC4R	L→P	2.66	25,173,201
TSHR	Y→N	5.58	19,204	V2R	R→W	3.26	192,205–208
TSHR	D→G	6.30	13,19,160	MC4R	I→K	3.28	25,49,173,185,195
TSHR	A→I,V	6.34	13,19,160,165,166	MC4R	I→T	3.40	25,172,173,194
MC4R	L→Q	6.40	19,46,48,172,173	V2R	Y→C	5.39	191,208–210
TSHR	L→F	6.40	18,19,61	V2R	P→H	7.50	75
TSHR	I→M	6.41	174
TSHR	F→L	6.42	19,211
TSHR	T→I	6.43	19,178,179
TSHR	C→W	6.47	212
MC4R	F→S	6.51	95
MC4R	I→T	7.52	48,172