. Author manuscript; available in PMC: 2016 Jan 19.

Published in final edited form as: Molecules. 2015 Jan 19;20(1):1643–1660. doi: 10.3390/molecules20011643

Table 1.

Dissociation constants determined by ITC and comparison with reported values.

Binding partner/ligand	Hsp90	Observed K_d (µM)	Reported K_d (µM)	Reference
p50^Cdc37	yHsp82-FL	n/d	1.46	[30]
	hΔHsp90β	1.1	n/a
	hHsp90β-N	4.4	n/a
	hHsp90β-FL	1.2	n/a
	h(p)Hsp90β-FL	1.7	n/a

(p)p50^Cdc37	hHsp90β-FL	5.1	n/a
(p)p50^Cdc37	h(p)Hsp90β-FL	8.6	n/a

ADP	hΔHsp90β	11	n/a	[31]
	hHsp90β-FL	8.9	7.2
	h(p)Hsp90β-FL	13	n/a

ATP	hΔHsp90β	43	n/a	[31]
	hHsp90β-FL	4.6	240
	h(p)Hsp90β-FL	11	n/a

AMP-PNP	hΔHsp90β	84	n/a	[31]
	hHsp90β-FL	85	148
	h(p)Hsp90β-FL	590	n/a

NVP-AUY922	hΔHsp90β	<0.01	n/a	[32]
	hHsp90β-FL	<0.01	0.0017
	h(p)Hsp90β-FL	0.1	n/a

17-DMAG	hHsp90β-FL	n/d	0.35	[33]
17-DMAG	hΔHsp90β	0.79	n/a	[33]

Radicicol	yHsp82-FL	n/d	0.019	[34]
Radicicol	hΔHsp90β	<0.01	n/a	[34]