Skip to main content
. Author manuscript; available in PMC: 2016 Jan 19.
Published in final edited form as: Molecules. 2015 Jan 19;20(1):1643–1660. doi: 10.3390/molecules20011643

Table 2.

Disruptive potential of small molecules against Hsp90β-p50Cdc37 complexes determined by ELISA.

IC50 (µM)

Complex ADP ATP AMP-PNP H2-GMZ H2-GMZ Gedunin NVP
Hsp90-p50Cdc37 500 ± 94 >1000 >1000 >1000 >1000 >1000 >1000
(p)Hsp90-p50Cdc37 220 ± 24 450 ± 150 >1000 >1000 >1000 >1000 >1000
Hsp90-(p)p50Cdc37 270 ± 35 >1000 n/d n/d n/d n/d n/d
(p)Hsp90-(p)p50Cdc37 32 ± 5.6 230 ± 40 >1000 >1000 >1000 >1000 >1000
ΔHsp90-p50Cdc37 400 ± 81 >1000 >1000 >1000 >1000 >1000 >1000